- hyperphosphorylated
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phosphorylated to a more than normal extent, or fully saturated with phosphate groups
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hyperphosphorylated
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Neurofibrillary tangle — Microscopy image of a neurofibrillary tangle, conformed by hyperphosphorylated tau protein Neurofibrillary Tangles (NFTs) are aggregates of hyperphosphorylated tau protein that are most commonly known as a primary marker of Alzheimer s Disease.… … Wikipedia
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Hyperphosphorylation — occurs when a biochemical with multiple phosphorylation sites is fully saturated. Hyperphosphorylation is one of the signalling mechanisms used by the cell to regulate mitosis. When these mechanisms fail, developmental problems or cancer are a… … Wikipedia
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Tau protein — Tau proteins are microtubule associated proteins that are abundant in neurons in the central nervous system and are less common elsewhere. They were discovered in 1975 in Marc Kirschner s laboratory at Princeton University… … Wikipedia
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RNA polymerase II — (also called RNAP II and Pol II) is an enzyme found in eukaryotic cells. It catalyzes the transcription of DNA to synthesize precursors of mRNA and most snRNA and microRNA. [cite journal | author = Kronberg, R.D. | title = Eukaryotic… … Wikipedia
Hereditary inclusion body myopathy — Hereditary inclusion body myopathies (HIBM) are a heterogeneous group of genetic disorders which have different symptoms. Generally, they are neuromuscular disorders characterized by muscle weakness developing in young adults. Hereditary… … Wikipedia
