- downregulation
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The process, in the regulation of gene expression, in which the number, or activity of receptors decreases in order to decrease sensitivity
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downregulation
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Downregulation and upregulation — Downregulation is the process by which a cell decreases the quantity of a cellular component, such as RNA or protein, in response to an external variable. An increase of a cellular component is called upregulation. An example of downregulation is … Wikipedia
downregulation — down·reg·u·la·tion dau̇n .reg yə lā shən n the process of reducing or suppressing a response to a stimulus specif reduction in a cellular response to a molecule (as insulin) due to a decrease in the number of receptors on the cell surface… … Medical dictionary
downregulation — ˈ ̷ ̷ ˌ ̷ ̷ ̷ ̷ ˌ ̷ ̷ ̷ ̷ noun Etymology: down + regulation (IV) : the process of reducing or suppressing a response to a stimulus ; specifically : reduction in a cellular response to a molecule (as of insulin) from a decrease in the number of… … Useful english dictionary
receptor downregulation — A phenomenon observed in many cells: following stimulation with a ligand the number of receptors for that ligand on the cell surface diminishes because internalisation exceeds replenishment. Often used very loosely, thus destroying the utility of … Dictionary of molecular biology
Chloride potassium symporter 5 — Solute carrier family 12 (potassium/chloride transporter), member 5 Identifiers Symbols SLC12A5; KCC2; KIAA1176 External IDs … Wikipedia
FSH-receptor — Follicle stimulating hormone receptor PDB rendering based on 1xwd … Wikipedia
Vesicle (biology and chemistry) — Scheme of a simple vesicle (liposome). A vesicle is a bubble of liquid within another liquid, a supramolecular assembly made up of many different molecules. More technically, a vesicle is a small membrane enclosed sack that can store or transport … Wikipedia
Vesicle (biology) — A vesicle is a small bubble of liquid within a cell. A more formal definition in cell biology, would be that a vesicle is a relatively small, intracellular, membrane enclosed sac that stores or transports substances. Vesicles form naturally… … Wikipedia
Reelin — is a protein found mainly in the brain, but also in the spinal cord, blood and other body organs and tissues. Reelin is crucial for regulating the processes of neuronal migration and positioning in the developing brain.Besides this important role … Wikipedia
Luteinizing hormone/choriogonadotropin receptor — The luteinizing hormone/choriogonadotropin receptor (LHCGR), also lutropin/choriogonadotropin receptor (LCGR) is a transmembrane receptor found in ovary, testis and extragonodal organs like uterus, that receptor interacts with both luteinizing… … Wikipedia
