1-methyl-4-phenylpyridinium
- 1-methyl-4-phenylpyridinium
-
a) MPP+, the active metabolite of
MPTP.
Apical uptake was higher than basolateral uptake at 37 degrees C and was decreased to 70% in the presence of NaN(3) or in the absence of extracellular Na(+). Besides alpha2-agonists, apical uptake was inhibited by verapamil, desipramine, and quinidine, but not by MPP(+) (1-methyl-4-phenylpyridinium), TEA (tetraethylammonium), decynium-22, carnitine, PHA (p-aminohippurate), alanine, or inosine.
b) A neurotoxin which cannot cross the blood brain barrier, but once in contact it can destroy the
dopaminergic neurons of the
substantia nigra.
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